Different cities with different functions play a variable role in regional development. This paper applies the nodal analysis to estimate the functional intensity of each central city in Anhui, concludes that Hefei and Wuhu rank the core position in economic development. Two cities are compared in their industries in order to judge their urban functions. Hefei city is relatively full-scale with advantages in the third industry, where is the economic center in Anhui, while Wuhu city has a single urban function with advantages in its manufacturing, where is one of major industrial centers. This paper presents some suggestions improving the urban functions and playing the leading role for the two cities